美国哥伦比亚大学段东升博士学术讲座

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基础医学院为促进医学相关学科的发展，加强国际交流，邀请美国密苏里－哥伦比亚大学分子微生物学免疫学系副教授、博士研究生导师段东升博士进行学术讲座。段东升博士主要从事细胞生物学、基因治疗、分子微生物学免疫学研究工作。主要研究方向为腺相关病毒(Adeno-associated Virus，AAV)转导细胞生物学，AAV介导基因治疗进行性假肥大性肌营养不良（Duchenne Muscular Dystrophy Skeletal Muscle Disease，DMD）、DMD的基因治疗、AAV介导的囊性纤维化的基因治疗。曾17次担任NIH研究基金特邀评审委员；美国基因治疗协会2个专家委员会成员；11种学术期刊Nat. Biotech., Mol. Ther., Hum. Genet., Hum. Mol. Genet., J. Gene Med., Gene Ther., Curr. Gene Ther., Am. J. Physiol. GI & Liver., Virology, Am. J. Physiol Lung Cell Mol Physiol, J. Virol. Method的特邀审稿专家。受NIH等多项研究资助，总金额约200多万美元。先后在Nature Medicine.；Nature Biotechnology；Development；Human Gene Therapy等期刊发表论文40篇。专利6项。　　题 目：分子微生物学在临床与免疫学中实践——基因治疗
　　主讲人： Dongsheng Duan
　　时 间： 2006年7月20 星期四上午 9:00－11:00
　　地 点： 兰州大学医学校区基础医学院2楼会议室
　　欢迎广大师生届时参加！
　　　　　　　　　　　　　　　　　　　　　　基础医学院
Selected Publications
1. Duan D, Yue Y, Yan Z, and Engelhardt JF. A New Dual Vector Approach to Enhance Recombinant AAV Mediated Gene Expression Through Intermolecular Cis-activation. Nature Medicine. 6:595-598 (2000).
2．Yue Y, Li, Z, Harper SQ, Davisson RL, Chamberlain JS, Duan D. Micro-dystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-Glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart. Circulation 108(13): 1626-32 (2003). (DD as corresponding author).
3．Yue Y, Skimming JW, Liu M, Strawn T, Duan D. Full-length Dystrophin Expression in Half of the Heart Cells Ameliorates -Isoproterenol-induced Cardiomyopathy in mdx mice. Human Molecular Genetics 13(15): 1669-1675 (2004). (DD as corresponding author).
4 . Xu Z, Yue Y, Lai Y, Zhang C, Qiu J, Pintel DJ, Duan D. Trans-splicing Adeno-associated Viral Vector-mediated Gene Therapy is Limited by the Accumulation of Spliced mRNA but not by Dual Vector Co-infection Efficiency. Human Gene Therapy 15(9): 896-905 (2004). (DD as corresponding author).
5. Liu M, Yue Y, Harper S, Grange R, Chamberlain JS, Duan D. Adeno-associated Virus-mediated Micro-dystrophin Expression Protects Young Mdx Muscle from Contraction-induced Injury. Molecular Therapy 11(2):245-256 (2005). (DD as corresponding author).
6. Lai Y, Yue Y, Liu M, Ghosh A, Engelhardt JF, Chamberlain JS, Duan D. Efficient Expression of the 6kb ∆H2-R19 Mini-dystrophin Gene by Trans-Splicing Adeno-Associated Viral Vectors Ameliorates Muscular Dystrophy in Mdx Mice. Nature Biotechnology 23(11):1435-1439 (2005). (DD as corresponding author).
7. Yue Y, Liu M, Duan D. C-Terminal Truncated Microdystrophin Recruits Dystrobrevin and Syntrophin to the Dystrophin-associated Glycoprotein Complex and Reduces Muscular Dystrophy in Symptomatic Utrophin/dystrophin Double Knockout Mice. Molecular Therapy 14(1):79-87, (2006). (DD as corresponding author).
8. Duan D. Challenges and Opportunities in Dystrophin-Deficient Cardiomyopathy Gene Therapy. Human Molecular Genetics, 2006,Vol. 15, Review Issue No. 2 R1-R9 in-press (DD as corresponding author).

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http://news.lzu.edu.cn/content/6164.shtml
美国前四位大学、哈佛、耶鲁、普林斯顿、哥伦比亚大学。段东升博士主要研究方向为腺相关病毒(Adeno-associated Virus，AAV)转导细胞生物学，AAV介导基因治疗进行性假肥大性肌营养不良（Duchenne Muscular Dystrophy Skeletal Muscle Disease，DMD）、DMD的基因治疗、AAV介导的囊性纤维化的基因治疗。又6年了不理想可能AAV腺病毒方向不对。

袁钦碧

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